| Summary: | Background. The preoperative platelet-to-lymphocyte ratio (PLR) evaluates the prognosis of gastric cancer patients. However, whether preoperative PLR may be used to evaluate the prognosis of mucinous gastric carcinoma (MGC) patients is poorly investigated. The present study evaluated the effect of preoperative PLR on overall survival in gastric cancer patients with a mucinous component. Methods. A total of 336 MGC were enrolled in this study, and the characteristics of the tumor, including pathological features and clinical data, were retrospectively analyzed. Results. A high PLR was associated with larger tumor size, advanced tumor invasion, lymph node metastasis, advanced TNM stage, tumor location, total gastrectomy, low hemoglobin level, low albumin level, high fibrinogen level, high platelet level, and high neutrophil-to-lymphocyte ratio (NLR, all P′s<0.05). Multivariate analysis identified age (HR=1.876; 95% CI 1.361-2.585, P<0.001), TNM stage (HR=2.350; 95% CI 1.216-4.542, P=0.011), globulin (HR=1.520; 95% CI 1.067-2.165, P=0.020), total gastrectomy (HR=0.537; 95% CI 0.373-0.772, P=0.001), and PLR (HR=1.582; 95% CI 1.066-2.348, P=0.023) as independent prognostic factors for OS. Conclusion. Preoperative PLR is related to pathological features and may independently evaluate the survival of MGC. Therefore, preoperative PLR may help physicians develop treatment plans and evaluate survival in these patients.
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