DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1

DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1

Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.

Bibliographic Details
Main Authors: Jing Ting Wong, Farzanah Akhbar, Amanda Yunn Ee Ng, Mandy Li-Ian Tay, Gladys Jing En Loi, Jun Wei Pek
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00684-4
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spelling doaj-f5b9004081984bb9a7ce59a01c81c5332021-05-11T07:28:50ZengNature Publishing GroupNature Communications2041-17232017-10-018111210.1038/s41467-017-00684-4DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1Jing Ting Wong0Farzanah Akhbar1Amanda Yunn Ee Ng2Mandy Li-Ian Tay3Gladys Jing En Loi4Jun Wei Pek5Ngee Ann PolytechnicTemasek PolytechnicTemasek Life Sciences Laboratory, 1 Research Link National University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link National University of SingaporeNational University of SingaporeTemasek Life Sciences Laboratory, 1 Research Link National University of SingaporeStable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.https://doi.org/10.1038/s41467-017-00684-4
collection DOAJ
language English
format Article
sources DOAJ
author Jing Ting Wong
Farzanah Akhbar
Amanda Yunn Ee Ng
Mandy Li-Ian Tay
Gladys Jing En Loi
Jun Wei Pek
spellingShingle Jing Ting Wong
Farzanah Akhbar
Amanda Yunn Ee Ng
Mandy Li-Ian Tay
Gladys Jing En Loi
Jun Wei Pek
DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1
Nature Communications
author_facet Jing Ting Wong
Farzanah Akhbar
Amanda Yunn Ee Ng
Mandy Li-Ian Tay
Gladys Jing En Loi
Jun Wei Pek
author_sort Jing Ting Wong
title DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1
title_short DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1
title_full DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1
title_fullStr DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1
title_full_unstemmed DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1
title_sort dip1 modulates stem cell homeostasis in drosophila through regulation of sisr-1
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.
url https://doi.org/10.1038/s41467-017-00684-4
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AT farzanahakhbar dip1modulatesstemcellhomeostasisindrosophilathroughregulationofsisr1
AT amandayunneeng dip1modulatesstemcellhomeostasisindrosophilathroughregulationofsisr1
AT mandyliiantay dip1modulatesstemcellhomeostasisindrosophilathroughregulationofsisr1
AT gladysjingenloi dip1modulatesstemcellhomeostasisindrosophilathroughregulationofsisr1
AT junweipek dip1modulatesstemcellhomeostasisindrosophilathroughregulationofsisr1
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