Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter
Recent developments in epidemiology have confirmed that airborne particulates are directly associated with respiratory pathology and mortality. Although clinical studies have yielded evidence of the effects of many types of fine particulates on human health, it still does not have a complete underst...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-05-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00519/full |
| id |
doaj-f5b8305b8b42455f85538d71822d2fdc |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jia-Wei Yang Jia-Wei Yang Yu-Chih Shen Yu-Chih Shen Ko-Chih Lin Ko-Chih Lin Sheng-Jen Cheng Sheng-Jen Cheng Shiue-Luen Chen Shiue-Luen Chen Chong-You Chen Chong-You Chen Priyank V. Kumar Shien-Fong Lin Shien-Fong Lin Huai-En Lu Guan-Yu Chen Guan-Yu Chen Guan-Yu Chen |
| spellingShingle |
Jia-Wei Yang Jia-Wei Yang Yu-Chih Shen Yu-Chih Shen Ko-Chih Lin Ko-Chih Lin Sheng-Jen Cheng Sheng-Jen Cheng Shiue-Luen Chen Shiue-Luen Chen Chong-You Chen Chong-You Chen Priyank V. Kumar Shien-Fong Lin Shien-Fong Lin Huai-En Lu Guan-Yu Chen Guan-Yu Chen Guan-Yu Chen Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter Frontiers in Bioengineering and Biotechnology particulate matter air pollution respiratory health cardiovascular effects organ-on-a-chip |
| author_facet |
Jia-Wei Yang Jia-Wei Yang Yu-Chih Shen Yu-Chih Shen Ko-Chih Lin Ko-Chih Lin Sheng-Jen Cheng Sheng-Jen Cheng Shiue-Luen Chen Shiue-Luen Chen Chong-You Chen Chong-You Chen Priyank V. Kumar Shien-Fong Lin Shien-Fong Lin Huai-En Lu Guan-Yu Chen Guan-Yu Chen Guan-Yu Chen |
| author_sort |
Jia-Wei Yang |
| title |
Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter |
| title_short |
Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter |
| title_full |
Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter |
| title_fullStr |
Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter |
| title_full_unstemmed |
Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter |
| title_sort |
organ-on-a-chip: opportunities for assessing the toxicity of particulate matter |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Bioengineering and Biotechnology |
| issn |
2296-4185 |
| publishDate |
2020-05-01 |
| description |
Recent developments in epidemiology have confirmed that airborne particulates are directly associated with respiratory pathology and mortality. Although clinical studies have yielded evidence of the effects of many types of fine particulates on human health, it still does not have a complete understanding of how physiological reactions are caused nor to the changes and damages associated with cellular and molecular mechanisms. Currently, most health assessment studies of particulate matter (PM) are conducted through cell culture or animal experiments. The results of such experiments often do not correlate with clinical findings or actual human reactions, and they also cause difficulty when investigating the causes of air pollution and associated human health hazards, the analysis of biomarkers, and the development of future pollution control strategies. Microfluidic-based cell culture technology has considerable potential to expand the capabilities of conventional cell culture by providing high-precision measurement, considerably increasing the potential for the parallelization of cellular assays, ensuring inexpensive automation, and improving the response of the overall cell culture in a more physiologically relevant context. This review paper focuses on integrating the important respiratory health problems caused by air pollution today, as well as the development and application of biomimetic organ-on-a-chip technology. This more precise experimental model is expected to accelerate studies elucidating the effect of PM on the human body and to reveal new opportunities for breakthroughs in disease research and drug development. |
| topic |
particulate matter air pollution respiratory health cardiovascular effects organ-on-a-chip |
| url |
https://www.frontiersin.org/article/10.3389/fbioe.2020.00519/full |
| work_keys_str_mv |
AT jiaweiyang organonachipopportunitiesforassessingthetoxicityofparticulatematter AT jiaweiyang organonachipopportunitiesforassessingthetoxicityofparticulatematter AT yuchihshen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT yuchihshen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT kochihlin organonachipopportunitiesforassessingthetoxicityofparticulatematter AT kochihlin organonachipopportunitiesforassessingthetoxicityofparticulatematter AT shengjencheng organonachipopportunitiesforassessingthetoxicityofparticulatematter AT shengjencheng organonachipopportunitiesforassessingthetoxicityofparticulatematter AT shiueluenchen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT shiueluenchen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT chongyouchen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT chongyouchen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT priyankvkumar organonachipopportunitiesforassessingthetoxicityofparticulatematter AT shienfonglin organonachipopportunitiesforassessingthetoxicityofparticulatematter AT shienfonglin organonachipopportunitiesforassessingthetoxicityofparticulatematter AT huaienlu organonachipopportunitiesforassessingthetoxicityofparticulatematter AT guanyuchen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT guanyuchen organonachipopportunitiesforassessingthetoxicityofparticulatematter AT guanyuchen organonachipopportunitiesforassessingthetoxicityofparticulatematter |
| _version_ |
1724592971412668416 |
| spelling |
doaj-f5b8305b8b42455f85538d71822d2fdc2020-11-25T03:26:25ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-05-01810.3389/fbioe.2020.00519512396Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate MatterJia-Wei Yang0Jia-Wei Yang1Yu-Chih Shen2Yu-Chih Shen3Ko-Chih Lin4Ko-Chih Lin5Sheng-Jen Cheng6Sheng-Jen Cheng7Shiue-Luen Chen8Shiue-Luen Chen9Chong-You Chen10Chong-You Chen11Priyank V. Kumar12Shien-Fong Lin13Shien-Fong Lin14Huai-En Lu15Guan-Yu Chen16Guan-Yu Chen17Guan-Yu Chen18Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanPh.D. Degree Program of Biomedical Science and Engineering, National Chiao Tung University, Hsinchu, TaiwanDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanSchool of Chemical Engineering, University of New South Wales, Sydney, NSW, AustraliaDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanBioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, TaiwanDepartment of Electrical and Computer Engineering, College of Electrical and Computer Engineering National Chiao Tung University, Hsinchu, TaiwanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, TaiwanDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu, TaiwanRecent developments in epidemiology have confirmed that airborne particulates are directly associated with respiratory pathology and mortality. Although clinical studies have yielded evidence of the effects of many types of fine particulates on human health, it still does not have a complete understanding of how physiological reactions are caused nor to the changes and damages associated with cellular and molecular mechanisms. Currently, most health assessment studies of particulate matter (PM) are conducted through cell culture or animal experiments. The results of such experiments often do not correlate with clinical findings or actual human reactions, and they also cause difficulty when investigating the causes of air pollution and associated human health hazards, the analysis of biomarkers, and the development of future pollution control strategies. Microfluidic-based cell culture technology has considerable potential to expand the capabilities of conventional cell culture by providing high-precision measurement, considerably increasing the potential for the parallelization of cellular assays, ensuring inexpensive automation, and improving the response of the overall cell culture in a more physiologically relevant context. This review paper focuses on integrating the important respiratory health problems caused by air pollution today, as well as the development and application of biomimetic organ-on-a-chip technology. This more precise experimental model is expected to accelerate studies elucidating the effect of PM on the human body and to reveal new opportunities for breakthroughs in disease research and drug development.https://www.frontiersin.org/article/10.3389/fbioe.2020.00519/fullparticulate matterair pollutionrespiratory healthcardiovascular effectsorgan-on-a-chip |