Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels

Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels

Voltage-gated sodium (Nav) channels play a central role in the generation and propagation of action potentials in excitable cells such as neurons and muscles. To determine how the phenotypes of Nav-channel mutants are affected by other genes, we performed a forward genetic screen for dominant modifi...

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Bibliographic Details
Main Authors: Hung-Lin Chen, Junko Kasuya, Patrick Lansdon, Garrett Kaas, Hanxi Tang, Maggie Sodders, Toshihiro Kitamoto
Format: Article
Language:English
Published: Oxford University Press 2020-04-01
Series:G3: Genes, Genomes, Genetics
Subjects:
forward genetic screen
genetic modifiers
epilepsy
rna-sequencing analysis
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.401025

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