Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation

Reduced Function and Diversity of T Cell Repertoire and Distinct Clinical Course in Patients With IL7RA Mutation

The alpha subunit of IL-7 receptor (IL7R7α) is critical for the differentiation of T cells, specifically for the development and maintenance of γδT cells. Mutations in IL7RA are associated with Severe Combined Immunodeficiency (SCID). Infants with IL7RA deficiency can be identified through newborn s...

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Bibliographic Details
Main Authors: Atar Lev, Amos J. Simon, Ortal Barel, Eran Eyal, Efrat Glick-Saar, Omri Nayshool, Ohad Birk, Tali Stauber, Amit Hochberg, Arnon Broides, Shlomo Almashanu, Ayal Hendel, Yu Nee Lee, Raz Somech
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
IIL7Rα
PID
SCID
NBS
TREC
immune repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01672/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01672/full

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