CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α.
Psychological stress is a predisposing factor in the onset and exacerbation of important gastrointestinal diseases including irritable bowel syndrome (IBS) and the inflammatory bowel diseases (IBD). The pathophysiology of stress-induced intestinal disturbances is known to be mediated by corticotropi...
Main Authors: | Elizabeth L Overman, Jean E Rivier, Adam J Moeser |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3386952?pdf=render |
Similar Items
-
Acute effect of cigarette smoke on TNF-α and proteases released by macrophages
by: Demirjian, Loutfig
Published: (2009) -
Histamine and TNF-α release by rat peritoneal mast cells stimulated with Trichomonas vaginalis
by: Im S.J., et al.
Published: (2011-02-01) -
Docosahexaenoic acid alleviates cell injury and improves barrier function by suppressing necroptosis signalling in TNF-α-challenged porcine intestinal epithelial cells
by: Kan Xiao, et al.
Published: (2020-11-01) -
Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis
by: Zijuan Zhou, et al.
Published: (2017-11-01) -
CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice.
by: Lixin Wang, et al.
Published: (2011-02-01)