CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α.

Psychological stress is a predisposing factor in the onset and exacerbation of important gastrointestinal diseases including irritable bowel syndrome (IBS) and the inflammatory bowel diseases (IBD). The pathophysiology of stress-induced intestinal disturbances is known to be mediated by corticotropi...

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Bibliographic Details
Main Authors: Elizabeth L Overman, Jean E Rivier, Adam J Moeser
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3386952?pdf=render

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