Upregulation of iNOS Protects Cyclic Mechanical Stretch-Induced Cell Death in Rat Aorta Smooth Muscle Cells

Upregulation of iNOS Protects Cyclic Mechanical Stretch-Induced Cell Death in Rat Aorta Smooth Muscle Cells

Aortic dissection and aneurysm are associated with abnormal hemodynamic loads originating from hypertension. Our previous study demonstrated that cyclic mechanical stretch (CMS, mimicked hypertension) caused the death of rat aortic smooth muscle cells (RASMCs) in a mitogen activated-protein kinases...

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Bibliographic Details
Main Authors: Jing Zhao, Kiichi Nakahira, Akihiko Kimura, Yoji Kyotani, Masanori Yoshizumi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
hypertension
NOS
stretch
vascular smooth muscle cell
cell death
Online Access:https://www.mdpi.com/1422-0067/21/22/8660

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