n-3 PUFAs modulate T-cell activation via protein kinase C-α and -ε and the NF-κB signaling pathway

n-3 PUFAs modulate T-cell activation via protein kinase C-α and -ε and the NF-κB signaling pathway

We elucidated the mechanisms of action of two n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in Jurkat T-cells. Both DHA and EPA were principally incorporated into phospholipids in the following order: phosphatidylcholine < phosphatidylethanolamine < phosphatidylinosito...

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Bibliographic Details
Main Authors: Anne Denys, Aziz Hichami, Naim Akhtar Khan
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Journal of Lipid Research
Subjects:
fatty acids
mitogen-activated protein kinase
polyunsaturated fatty acids
nuclear factor κB
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520340104

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