Mechanical Stretch Induces Smooth Muscle Cell Dysfunction by Regulating ACE2 via P38/ATF3 and Post-transcriptional Regulation by miR-421

Mechanical Stretch Induces Smooth Muscle Cell Dysfunction by Regulating ACE2 via P38/ATF3 and Post-transcriptional Regulation by miR-421

Mechanical stretch promotes deregulation of vascular smooth muscle cell (VSMC) functions during hypertension-induced vascular remodeling. ACE2 has a wide range of cardiovascular and renal protective effects. Loss of ACE2 is associated with cardiovascular disease, but little is known about the regula...

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Bibliographic Details
Main Authors: Xiaolin Liu, Xinxin Liu, Mengmeng Li, Yu Zhang, Weijia Chen, Meng Zhang, Cheng Zhang, Mei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
angiotensin-converting enzyme 2
mechanical stretch
vascular smooth muscle cells
P38 MAPK
ATF3
miR-421
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.540591/full

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