Expression and Clinical Significance of Bromodomain-containing Protein 7 in Non-small Cell Lung Cancer

• Main Authors: Long CHEN, Fenglei YU
• Format: Article
• Language: zho
• Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2011-10-01
• Series: Chinese Journal of Lung Cancer
• Subjects: Lung neoplasms; Bromodomain-containing protein 7; Immunohistochemistry
• Online Access: http://dx.doi.org/10.3779/j.issn.1009-3419.2011.10.11
• ISSN: 1009-3419; 1999-6187

Background and objective The bromodomain-containing protein 7 (BRD7) gene belongs to the bromodomain family. The majority of the members of this family are closely related to epithelial tumors. The aim of this study is to explore BRD7 expression and its clinical significance in non-small cell lung cancer (NSCLC). Methods BRD7 protein expression was detected in tissues samples from 101 NSCLC cases and 33 normal lung tissue samples using streptavidin-peroxidase immunohistochemistry. Results BRD7 expression was significantly higher in cancer tissues than that in normal lung tissues. Positive BRD7 expression in the lymph node metastasis group was significantly higher than that in the non-lymph node metastasis group. The positive expression rate of BRD7 increased with the increasing Tumor-Nodes-Metastasis (TNM) stage. No significant differences in positive BRD7 expression were observed with age, smoking, gender, pathology type, and degree of differentiation among the NSCLC patients (P>0.05). Conclusion BRD7 is highly expressed in NSCLC. In addition to the degree of differentiation and extent of lymphatic metastasis, BRD7 expression is correlated with TNM stage, which indicates that BRD7 may be related to the occurrence, development, and metastasis of lung cancers.