Management guidelines of penile cancer- a contemporary review of sub-Saharan Africa

• Main Authors: Ayun Cassell, Bashir Yunusa, Burgess Manobah, Desire Wambo
• Format: Article
• Language: English
• Published: BMC 2020-05-01
• Series: Infectious Agents and Cancer
• Subjects: Human papilloma virus; Penectomy; Penile Cancer; Sub-Saharan Africa
• Online Access: http://link.springer.com/article/10.1186/s13027-020-00293-9

Abstract Background Penile cancer is a rare malignancy with prevalence higher in areas of high Human Papilloma Virus (HPV) such as Africa, Asia and South America. In middle- and low-income countries where circumcision is not routinely practiced, the rate of penile cancer could be ten times higher. Main body of the abstract A literature review was conducted from 1992 to 2019 using PubMed, Google Scholar, African Journal Online and Google with inclusion of 27 publications with emphasis on the Sub-Saharan literature. Findings revealed that most men with penile cancer in Sub-Saharan Africa (SSA) present with locally advanced to advanced disease with devastating consequences. The option of penile sparing procedure is reduced with most treatment option directed to mutilating surgeries. The lack of appropriate chemotherapy and radiotherapy worsens the prognosis in the region. Short conclusion Human Papilloma Virus (HPV) vaccination may not be cost-effective for most regions in SSA. Therefore, early childhood circumcision might be the best advocated alternative for prevention.