A short update on the structure of drug binding sites on neurotransmitter transporters

A short update on the structure of drug binding sites on neurotransmitter transporters

<p>Abstract</p> <p>Background</p> <p>The dopamine (DAT), noradrenalin (NET) and serotonin (SERT) transporters are molecular targets for different classes of psychotropic drugs. Cocaine and the SSRI (<it>S</it>)-citalopram block neurotransmitter reuptake comp...

Full description

Bibliographic Details
Main Authors:	Gabrielsen Mari, Sylte Ingebrigt, Dahl Svein G, Ravna Aina W
Format:	Article
Language:	English
Published:	BMC 2011-12-01
Series:	BMC Research Notes
Online Access:	http://www.biomedcentral.com/1756-0500/4/559

Similar Items

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure
by: Sager Georg, et al.
Published: (2009-09-01)

The GABA<sub>B</sub> Receptor—Structure, Ligand Binding and Drug Development
by: Linn Samira Mari Evenseth, et al.
Published: (2020-07-01)

Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy.
by: Yan Baglo, et al.
Published: (2013-01-01)

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)
by: Sager Georg, et al.
Published: (2007-09-01)

Cocaine Binding Site from the Structure Function Analysis of the Neurotransmitter Reuptake Transporters
by: Hill, Erik R.
Published: (2010)

Comparative Molecular Dynamics Simulations of Mitogen-Activated Protein Kinase-Activated Protein Kinase 5
by: Inger Lindin, et al.
Published: (2014-03-01)

In Silico Methods for the Discovery of Orthosteric GABAB Receptor Compounds
by: Linn M. Evenseth, et al.
Published: (2019-03-01)

Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor.
by: Thibaud Freyd, et al.
Published: (2017-01-01)

Glutathione as a neurotransmitter in primary visual cortex : binding sites and neuronal uptake
by: Bowlsby, Stephen
Published: (2010)

MDMA and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicit
by: Nor Suliana Mustafa, et al.
Published: (2020-07-01)

Neurotransmitter uptake and binding in ischaemia and organic dementia
by: Goodhart, M. J.
Published: (1980)

Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters
by: Shabareesh Pidathala, et al.
Published: (2021-04-01)

Calcium transport in relation to neurotransmitter release
by: White, E. J.
Published: (1986)

Neurotransmitter Release Site Replenishment and Presynaptic Plasticity
by: Sumiko Mochida
Published: (2021-12-01)

Electronic Structure Based Classification of Neurotransmitters and Related Drugs
by: Jha, Amrita
Published: (2010)

Structure and Gating Dynamics of Na+/Cl– Coupled Neurotransmitter Transporters
by: Deepthi Joseph, et al.
Published: (2019-09-01)

Four-dimensional multi-site photolysis of caged neurotransmitters
by: Mary Ann eGo, et al.
Published: (2013-12-01)

Structure and spectroscopy of neurotransmitters
by: Butz, Patrick
Published: (2003)

Co-existence of functionally different vesicular neurotransmitter transporters
by: Agnieszka eMünster-Wandowski, et al.
Published: (2016-02-01)

Regulated Expression and Function of the Somatodendritic Catecholamine Neurotransmitter Transporters
by: Shigeo Kitayama, et al.
Published: (2005-01-01)

In silico approaches for characterizing neurotransmitter transporters and ion channels
by: Christopher K. Surratt, et al.
Published: (2016-01-01)

Effect of opiates on the transport of neurotransmitters in rat brain synaptosomes.
Published: (1983)

Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors.
by: Jeppe A Olsen, et al.
Published: (2014-01-01)

Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter
by: Lokeswari P. Tangella, et al.
Published: (2021-01-01)

Isolation and characterisation of a novel neurotransmitter transporter in Drosophila melanogaster
by: Johnson, Kevin
Published: (1995)

Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs
by: Hamid R. Noori, et al.
Published: (2018-11-01)

The action of psychoactive drugs on the release of neurotransmitters in the brains of conditioned animals
by: Patel, Hashumati Dajibhai Laxman
Published: (1984)

Effects of some central neurotransmitters and drugs on the cyclic GMP content of chick brain
by: Pratt, Christopher N. F. W.
Published: (1978)

Emerging Therapeutics Based on the Amino Acid Neurotransmitter System: An Update on the Pharmaceutical Pipeline for Mood Disorders
by: Julia Hecking, et al.
Published: (2021-05-01)

Homology modelling of metabotropic glutamate receptor 2
by: Mordalski S, et al.
Published: (2011-04-01)

Neurotransmitters and Emotions
Published: (2020)

Algorithms of the growth of flexible molecular structures in drug-binding sites
by: Todorov, Nikolay Pavlov
Published: (1995)

Systematic exploration of multiple drug binding sites
by: Mónika Bálint, et al.
Published: (2017-12-01)

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
by: Simon Erlendsson, et al.
Published: (2017-01-01)

Influence of cellular environments on PET ligand binding : an application to imaging endogenous neurotransmitter release
by: Quelch, Darren
Published: (2013)

Purification of β-bungarotoxin : its effects on the release of neurotransmitters and its binding to brain synaptosomes
by: Spokes, John William
Published: (1982)

Characterizing the transport and utilization of the neurotransmitter GABA in the bacterial pathogen Brucella abortus.
by: James A Budnick, et al.
Published: (2020-01-01)

Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
by: Joeri eVan Liefferinge, et al.
Published: (2013-08-01)

Single-Molecule Imaging of Conformational Dynamics in a Neurotransmitter Transporter Homolog
by: Kolster, Rachel Ann
Published: (2016)

New Aspects of Neurotransmitter Releasee and Exocytosis: Regulation of Neurotransmitter Release by Phosphorylation
by: Masami Takahashi, et al.
Published: (2003-01-01)