DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence.

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence.

Quiescence, an actively-maintained reversible state of cell cycle arrest, is not well understood. PTEN is one of the most frequently lost tumor suppressors in human cancers and regulates quiescence of stem cells and cancer cells. The sole PTEN ortholog in Caenorhabditis elegans is daf-18. In a C. el...

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Bibliographic Details
Main Authors: Amanda L Fry, Amy K Webster, Julia Burnett, Rojin Chitrakar, L Ryan Baugh, E Jane Albert Hubbard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009650

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