A lack of immune system genes causes loss in high frequency hearing but does not disrupt cochlear synapse maturation in mice.
Early cochlear development is marked by an exuberant outgrowth of neurites that innervate multiple targets. The establishment of mature cochlear neural circuits is, however, dependent on the pruning of inappropriate axons and synaptic connections. Such refinement also occurs in the central nervous s...
Main Authors: | Melissa A Calton, Dasom Lee, Srividya Sundaresan, Diana Mendus, Rose Leu, Felix Wangsawihardja, Kenneth R Johnson, Mirna Mustapha |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4012943?pdf=render |
Similar Items
-
Protection of Cochlear Ribbon Synapses and Prevention of Hidden Hearing Loss
by: Mei Wei, et al.
Published: (2020-01-01) -
Lack of Cdkl5 disrupts the organization of excitatory and inhibitory synapses and parvalbumin interneurons in the primary visual cortex
by: Riccardo Pizzo, et al.
Published: (2016-11-01) -
Cochlear Microphonics in Hearing Preservation Cochlear Implantees
by: Artur Lorens, et al.
Published: (2019-12-01) -
Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in Neonatal Cochlear Explants
by: Qiong Liang, et al.
Published: (2019-10-01) -
Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate
by: Richard Seist, et al.
Published: (2020-07-01)