Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway

Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway

Chimeric antigen receptor T (CAR-T) cell therapy has been applied successfully in treating hematologic malignancies; however, it shows very limited efficacy in treating solid tumors. Adenosine is one of the key immunosuppressive metabolites in tumor microenvironment (TME) of solid tumors. Although t...

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Bibliographic Details
Main Authors: Na Li, Na Tang, Chen Cheng, Tao Hu, Xiaofei Wei, Weidong Han, Haoyi Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
car-t cell
solid tumor
a2ar
crispr
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1824643

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