MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD+ biosynthetic enzyme NMNAT2 that inhibits activation of the SARM1 pathway. Here we investi...

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Bibliographic Details
Main Authors: Lauren J Walker, Daniel W Summers, Yo Sasaki, EJ Brace, Jeffrey Milbrandt, Aaron DiAntonio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
MAPK
NMNAT2
Axon degeneration
SCG10
SARM1
JNK
Online Access:https://elifesciences.org/articles/22540

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