A Hybrid Ensemble Approach for Identifying Robust Differentially Methylated Loci in Pan-Cancers

A Hybrid Ensemble Approach for Identifying Robust Differentially Methylated Loci in Pan-Cancers

DNA methylation is a widely investigated epigenetic mark that plays a vital role in tumorigenesis. Advancements in high-throughput assays, such as the Infinium 450K platform, provide genome-scale DNA methylation landscapes in single-CpG locus resolution, and the identification of differentially meth...

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Bibliographic Details
Main Authors: Qi Tian, Jianxiao Zou, Yuan Fang, Zhongli Yu, Jianxiong Tang, Ying Song, Shicai Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Genetics
Subjects:
DNA methylation
differentially methylated loci
ensemble feature selection
robustness
pan-cancers
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00774/full

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