The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model

The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model

Although the permeation mechanisms for K+ and Na+ channels have been extensively studied, the ion permeation mechanism through Ca2+ channels was largely unknown. Here the authors develop a multisite Ca2+ model that can be used in the framework of classical MD simulations to study Ca2+ in a quantitat...

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Main Authors: Aihua Zhang, Hua Yu, Chunhong Liu, Chen Song
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14573-w
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spelling doaj-f55196e6cf0f477e937e78a85ea0e7bb2021-05-11T08:30:04ZengNature Publishing GroupNature Communications2041-17232020-02-0111111010.1038/s41467-020-14573-wThe Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion modelAihua Zhang0Hua Yu1Chunhong Liu2Chen Song3Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking UniversityCenter for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking UniversityCenter for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking UniversityCenter for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking UniversityAlthough the permeation mechanisms for K+ and Na+ channels have been extensively studied, the ion permeation mechanism through Ca2+ channels was largely unknown. Here the authors develop a multisite Ca2+ model that can be used in the framework of classical MD simulations to study Ca2+ in a quantitative manner, and use it to investigate the ion permeation mechanism of the ryanodine receptor 1.https://doi.org/10.1038/s41467-020-14573-w
collection DOAJ
language English
format Article
sources DOAJ
author Aihua Zhang
Hua Yu
Chunhong Liu
Chen Song
spellingShingle Aihua Zhang
Hua Yu
Chunhong Liu
Chen Song
The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
Nature Communications
author_facet Aihua Zhang
Hua Yu
Chunhong Liu
Chen Song
author_sort Aihua Zhang
title The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_short The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_full The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_fullStr The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_full_unstemmed The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
title_sort ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-02-01
description Although the permeation mechanisms for K+ and Na+ channels have been extensively studied, the ion permeation mechanism through Ca2+ channels was largely unknown. Here the authors develop a multisite Ca2+ model that can be used in the framework of classical MD simulations to study Ca2+ in a quantitative manner, and use it to investigate the ion permeation mechanism of the ryanodine receptor 1.
url https://doi.org/10.1038/s41467-020-14573-w
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