The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo Hospital

Background Diabetes mellitus is a common complication in pa- tients with thalassemia major. Iron overload plays an important role by damaging the pancreatic β-cell and the liver cell, with the con- sequences of insulin deficiency and insulin resistance. Family his- tory of diabetes mellitus is one o...

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Main Authors: Caroline Mulawi, Bambang Tridjaja, Maria Abdulsalam, Zakiudin Munasir
Format: Article
Language:English
Published: Indonesian Pediatric Society Publishing House 2016-09-01
Series:Paediatrica Indonesiana
Subjects:
Online Access:https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/673
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spelling doaj-f53f012518074a29915953e362345b052020-11-25T02:46:51ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-09-014341172010.14238/pi43.4.2003.117-20539The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo HospitalCaroline MulawiBambang TridjajaMaria AbdulsalamZakiudin MunasirBackground Diabetes mellitus is a common complication in pa- tients with thalassemia major. Iron overload plays an important role by damaging the pancreatic β-cell and the liver cell, with the con- sequences of insulin deficiency and insulin resistance. Family his- tory of diabetes mellitus is one of the critical factors for the devel- opment of glucose metabolism derangement. However, the patho- genesis of glucose metabolism derangement remains unclear. Objective To evaluate the prevalence of impaired glucose toler- ance, diabetes mellitus, and insulin resistance in patients with β- thalassemia major treated in the Thalassemia Outpatient Clinic, Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta. Methods This was a descriptive cross sectional study conducted in May 2002. Forty-eight subjects aged 10 to 18 years, grouped by total volume of transfusions and family history of diabetes mellitus, underwent an oral glucose tolerance test (OGTT), serum transfer- rin saturation, and insulin level examinations. Insulin resistance was calculated from fasting plasma glucose and insulin concen- trations using the homeostasis model assessment (HOMA). Results One of 48 patients (2%) had impaired glucose tolerance at the age of 17 years. Diabetes mellitus occurred in three of 48 patients (6%) at the age of 15.5 years in one patient and 18 years in two patients. Family history of diabetes mellitus was found in 2 patients with diabetes mellitus and in the only one with impaired glucose tolerance. Insulin resistance was not detected in this study. Conclusion The prevalence of glucose metabolism derangement in patients with thalassemia major was low. No insulin resistance was found in this studyhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/673thalassemiaimpaired glucose tolerancediabetes mellitusinsulin resistance
collection DOAJ
language English
format Article
sources DOAJ
author Caroline Mulawi
Bambang Tridjaja
Maria Abdulsalam
Zakiudin Munasir
spellingShingle Caroline Mulawi
Bambang Tridjaja
Maria Abdulsalam
Zakiudin Munasir
The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo Hospital
Paediatrica Indonesiana
thalassemia
impaired glucose tolerance
diabetes mellitus
insulin resistance
author_facet Caroline Mulawi
Bambang Tridjaja
Maria Abdulsalam
Zakiudin Munasir
author_sort Caroline Mulawi
title The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo Hospital
title_short The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo Hospital
title_full The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo Hospital
title_fullStr The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo Hospital
title_full_unstemmed The prevalence of insulin resistance in patients with β -thalassemia major at Cipto Mangunkusumo Hospital
title_sort prevalence of insulin resistance in patients with β -thalassemia major at cipto mangunkusumo hospital
publisher Indonesian Pediatric Society Publishing House
series Paediatrica Indonesiana
issn 0030-9311
2338-476X
publishDate 2016-09-01
description Background Diabetes mellitus is a common complication in pa- tients with thalassemia major. Iron overload plays an important role by damaging the pancreatic β-cell and the liver cell, with the con- sequences of insulin deficiency and insulin resistance. Family his- tory of diabetes mellitus is one of the critical factors for the devel- opment of glucose metabolism derangement. However, the patho- genesis of glucose metabolism derangement remains unclear. Objective To evaluate the prevalence of impaired glucose toler- ance, diabetes mellitus, and insulin resistance in patients with β- thalassemia major treated in the Thalassemia Outpatient Clinic, Department of Child Health, Cipto Mangunkusumo Hospital, Jakarta. Methods This was a descriptive cross sectional study conducted in May 2002. Forty-eight subjects aged 10 to 18 years, grouped by total volume of transfusions and family history of diabetes mellitus, underwent an oral glucose tolerance test (OGTT), serum transfer- rin saturation, and insulin level examinations. Insulin resistance was calculated from fasting plasma glucose and insulin concen- trations using the homeostasis model assessment (HOMA). Results One of 48 patients (2%) had impaired glucose tolerance at the age of 17 years. Diabetes mellitus occurred in three of 48 patients (6%) at the age of 15.5 years in one patient and 18 years in two patients. Family history of diabetes mellitus was found in 2 patients with diabetes mellitus and in the only one with impaired glucose tolerance. Insulin resistance was not detected in this study. Conclusion The prevalence of glucose metabolism derangement in patients with thalassemia major was low. No insulin resistance was found in this study
topic thalassemia
impaired glucose tolerance
diabetes mellitus
insulin resistance
url https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/673
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