Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation

Abstract The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific activation of the inflammasomes, we...

Full description

Bibliographic Details
Main Authors: Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V. Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07014-0

Similar Items

Similar Items