Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

Abstract Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs. Calcitonin gene-related peptide, transient receptor potential vanilloid-1 receptor, and neuronal nitri...

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Bibliographic Details
Main Authors: Eleonóra Spekker, Klaudia Flóra Laborc, Zsuzsanna Bohár, Gábor Nagy-Grócz, Annamária Fejes-Szabó, Mónika Szűcs, László Vécsei, Árpád Párdutz
Format: Article
Language:English
Published: BMC 2021-03-01
Series:The Journal of Headache and Pain
Subjects:
Migraine
Trigeminal system
Inflammatory soup
Sumatriptan
Kynurenic acid
CGRP
Online Access:https://doi.org/10.1186/s10194-021-01229-3

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