Upregulation of Matrix Metalloproteinase-9 in Primary Cultured Rat Astrocytes Induced by 2-Chloroethanol Via MAPK Signal Pathways

Upregulation of Matrix Metalloproteinase-9 in Primary Cultured Rat Astrocytes Induced by 2-Chloroethanol Via MAPK Signal Pathways

2-Chloroethanol (2-CE) is one of the reactive metabolites of 1,2-DCE in vivo, which might contribute to brain edema formation induced by 1,2-dichloroethane (1,2-DCE) poisoning. Thus, the purpose of this study was to explore the roles of mitogen-activated protein kinase (MAPK) signal pathways in upre...

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Bibliographic Details
Main Authors: Tong Wang, Yingjun Liao, Qi Sun, Hongge Tang, Gaoyang Wang, Fenghong Zhao, Yaping Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
2-chloroethanol
astrocytes
mitogen-activated protein kinase signal pathway
matrix metalloproteinases-9
1
2-dichloroethane poisoning
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00218/full

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