Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applie...

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Bibliographic Details
Main Authors: Masataka Kawakita, Taiki Oyama, Ikuma Shirai, Shuto Tanaka, Kotaro Akaki, Shinya Abe, Takuma Asahi, Guangwei Cui, Fumie Itoh, Masato Sasaki, Nobuyuki Shibata, Koichi Ikuta, Tomomitsu Hatakeyama, Kazuhiko Takahara
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01870-3

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