Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applie...

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Main Authors:	Masataka Kawakita, Taiki Oyama, Ikuma Shirai, Shuto Tanaka, Kotaro Akaki, Shinya Abe, Takuma Asahi, Guangwei Cui, Fumie Itoh, Masato Sasaki, Nobuyuki Shibata, Koichi Ikuta, Tomomitsu Hatakeyama, Kazuhiko Takahara
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-01870-3

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spelling	doaj-f517422173d447fa8da01bb742db42d02021-03-21T12:29:00ZengNature Publishing GroupCommunications Biology2399-36422021-03-01411910.1038/s42003-021-01870-3Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsisMasataka Kawakita0Taiki Oyama1Ikuma Shirai2Shuto Tanaka3Kotaro Akaki4Shinya Abe5Takuma Asahi6Guangwei Cui7Fumie Itoh8Masato Sasaki9Nobuyuki Shibata10Koichi Ikuta11Tomomitsu Hatakeyama12Kazuhiko Takahara13Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto UniversityDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto UniversityDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto UniversityDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto UniversityDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto UniversityLaboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto UniversityLaboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto UniversityLaboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto UniversityDivision of Infection and Host Defense, Tohoku Medical and Pharmaceutical UniversityDivision of Infection and Host Defense, Tohoku Medical and Pharmaceutical UniversityDivision of Infection and Host Defense, Tohoku Medical and Pharmaceutical UniversityLaboratory of Immune Regulation, Department of Virus Research, Institute for Frontier Life and Medical Sciences, Kyoto UniversityBiomolecular Chemistry Laboratory, Graduate School of Engineering, Nagasaki UniversityDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto UniversityKawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applied to attenuate a severe inflammation caused by another pathogen.https://doi.org/10.1038/s42003-021-01870-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Masataka Kawakita Taiki Oyama Ikuma Shirai Shuto Tanaka Kotaro Akaki Shinya Abe Takuma Asahi Guangwei Cui Fumie Itoh Masato Sasaki Nobuyuki Shibata Koichi Ikuta Tomomitsu Hatakeyama Kazuhiko Takahara
spellingShingle	Masataka Kawakita Taiki Oyama Ikuma Shirai Shuto Tanaka Kotaro Akaki Shinya Abe Takuma Asahi Guangwei Cui Fumie Itoh Masato Sasaki Nobuyuki Shibata Koichi Ikuta Tomomitsu Hatakeyama Kazuhiko Takahara Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis Communications Biology
author_facet	Masataka Kawakita Taiki Oyama Ikuma Shirai Shuto Tanaka Kotaro Akaki Shinya Abe Takuma Asahi Guangwei Cui Fumie Itoh Masato Sasaki Nobuyuki Shibata Koichi Ikuta Tomomitsu Hatakeyama Kazuhiko Takahara
author_sort	Masataka Kawakita
title	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_short	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_full	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_fullStr	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_full_unstemmed	Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
title_sort	cell wall n-glycan of candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis
publisher	Nature Publishing Group
series	Communications Biology
issn	2399-3642
publishDate	2021-03-01
description	Kawakita et al use a murine sepsis model to show that N-glycan from pathogenic C. albicans ameliorates sepsis - and thus improves survival - through upregulation of the cytokine IL-10. This study demonstrates a potential strategy in which the immunosuppressive mechanism of one pathogen can be applied to attenuate a severe inflammation caused by another pathogen.
url	https://doi.org/10.1038/s42003-021-01870-3
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Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

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