Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there ex...
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doaj-f51407953cd0413a84590fc8f8fd8f002020-11-25T00:39:57ZengElsevierGynecologic Oncology Reports2352-57892018-11-01263740Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluationAlyssa Wield0Melissa Hodeib1Mohammad Khan2Lindsay Gubernick3Andrew J. Li4Shivani Kandukuri5Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United States; Corresponding author at: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Suite 3622, Los Angeles, CA 90048, United States.Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United StatesDepartment of Pathology, Cedars-Sinai Medical Center, United StatesDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United StatesDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United StatesDepartment of Pathology, Cedars-Sinai Medical Center, United StatesSebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there exists a strong association between this rare tumor and hereditary syndromes of DNA mismatch repair deficiency, such as Lynch syndrome and the lesser-known Muir-Torre syndrome. Here we present the case of a 67 year-old woman with a longstanding history of a small left ovarian cyst with sonographic features of an ovarian dermoid. After nine years, the left adnexal mass was noted to have enlarged, and she underwent a laparoscopic bilateral salpingo-oophorectomy. The final pathology was reported as sebaceous carcinoma arising within a mature cystic teratoma. The patient underwent subsequent surgical staging and has been followed for eight months without evidence of disease. This report includes a review of the current literature, as well as a brief discussion of the clinical management of women with sebaceous carcinoma arising within a mature teratoma. Additionally, we comment on the broader, hereditary significance of a diagnosis of sebaceous carcinoma, and use this case to demonstrate the thorough histologic and genetic evaluation that is recommended for patients diagnosed with this rare tumor. Keywords: Sebaceous carcinoma, Mature cystic teratoma, Dermoid cyst, Lynch syndrome, Muir-Torre syndrome, Hereditary nonpolyposis colorectal cancer (HNPCC)http://www.sciencedirect.com/science/article/pii/S2352578918300857 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alyssa Wield Melissa Hodeib Mohammad Khan Lindsay Gubernick Andrew J. Li Shivani Kandukuri |
spellingShingle |
Alyssa Wield Melissa Hodeib Mohammad Khan Lindsay Gubernick Andrew J. Li Shivani Kandukuri Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation Gynecologic Oncology Reports |
author_facet |
Alyssa Wield Melissa Hodeib Mohammad Khan Lindsay Gubernick Andrew J. Li Shivani Kandukuri |
author_sort |
Alyssa Wield |
title |
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation |
title_short |
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation |
title_full |
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation |
title_fullStr |
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation |
title_full_unstemmed |
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation |
title_sort |
sebaceous carcinoma arising within an ovarian mature cystic teratoma: a case report with discussion of clinical management and genetic evaluation |
publisher |
Elsevier |
series |
Gynecologic Oncology Reports |
issn |
2352-5789 |
publishDate |
2018-11-01 |
description |
Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there exists a strong association between this rare tumor and hereditary syndromes of DNA mismatch repair deficiency, such as Lynch syndrome and the lesser-known Muir-Torre syndrome. Here we present the case of a 67 year-old woman with a longstanding history of a small left ovarian cyst with sonographic features of an ovarian dermoid. After nine years, the left adnexal mass was noted to have enlarged, and she underwent a laparoscopic bilateral salpingo-oophorectomy. The final pathology was reported as sebaceous carcinoma arising within a mature cystic teratoma. The patient underwent subsequent surgical staging and has been followed for eight months without evidence of disease. This report includes a review of the current literature, as well as a brief discussion of the clinical management of women with sebaceous carcinoma arising within a mature teratoma. Additionally, we comment on the broader, hereditary significance of a diagnosis of sebaceous carcinoma, and use this case to demonstrate the thorough histologic and genetic evaluation that is recommended for patients diagnosed with this rare tumor. Keywords: Sebaceous carcinoma, Mature cystic teratoma, Dermoid cyst, Lynch syndrome, Muir-Torre syndrome, Hereditary nonpolyposis colorectal cancer (HNPCC) |
url |
http://www.sciencedirect.com/science/article/pii/S2352578918300857 |
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