Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation

Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there ex...

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Main Authors: Alyssa Wield, Melissa Hodeib, Mohammad Khan, Lindsay Gubernick, Andrew J. Li, Shivani Kandukuri
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Gynecologic Oncology Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2352578918300857
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spelling doaj-f51407953cd0413a84590fc8f8fd8f002020-11-25T00:39:57ZengElsevierGynecologic Oncology Reports2352-57892018-11-01263740Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluationAlyssa Wield0Melissa Hodeib1Mohammad Khan2Lindsay Gubernick3Andrew J. Li4Shivani Kandukuri5Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United States; Corresponding author at: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Suite 3622, Los Angeles, CA 90048, United States.Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United StatesDepartment of Pathology, Cedars-Sinai Medical Center, United StatesDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United StatesDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, United StatesDepartment of Pathology, Cedars-Sinai Medical Center, United StatesSebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there exists a strong association between this rare tumor and hereditary syndromes of DNA mismatch repair deficiency, such as Lynch syndrome and the lesser-known Muir-Torre syndrome. Here we present the case of a 67 year-old woman with a longstanding history of a small left ovarian cyst with sonographic features of an ovarian dermoid. After nine years, the left adnexal mass was noted to have enlarged, and she underwent a laparoscopic bilateral salpingo-oophorectomy. The final pathology was reported as sebaceous carcinoma arising within a mature cystic teratoma. The patient underwent subsequent surgical staging and has been followed for eight months without evidence of disease. This report includes a review of the current literature, as well as a brief discussion of the clinical management of women with sebaceous carcinoma arising within a mature teratoma. Additionally, we comment on the broader, hereditary significance of a diagnosis of sebaceous carcinoma, and use this case to demonstrate the thorough histologic and genetic evaluation that is recommended for patients diagnosed with this rare tumor. Keywords: Sebaceous carcinoma, Mature cystic teratoma, Dermoid cyst, Lynch syndrome, Muir-Torre syndrome, Hereditary nonpolyposis colorectal cancer (HNPCC)http://www.sciencedirect.com/science/article/pii/S2352578918300857
collection DOAJ
language English
format Article
sources DOAJ
author Alyssa Wield
Melissa Hodeib
Mohammad Khan
Lindsay Gubernick
Andrew J. Li
Shivani Kandukuri
spellingShingle Alyssa Wield
Melissa Hodeib
Mohammad Khan
Lindsay Gubernick
Andrew J. Li
Shivani Kandukuri
Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
Gynecologic Oncology Reports
author_facet Alyssa Wield
Melissa Hodeib
Mohammad Khan
Lindsay Gubernick
Andrew J. Li
Shivani Kandukuri
author_sort Alyssa Wield
title Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
title_short Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
title_full Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
title_fullStr Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
title_full_unstemmed Sebaceous carcinoma arising within an ovarian mature cystic teratoma: A case report with discussion of clinical management and genetic evaluation
title_sort sebaceous carcinoma arising within an ovarian mature cystic teratoma: a case report with discussion of clinical management and genetic evaluation
publisher Elsevier
series Gynecologic Oncology Reports
issn 2352-5789
publishDate 2018-11-01
description Sebaceous carcinomas are rare tumors, with the majority of described cases occurring within the eyelid. To date, there are nine documented reports of sebaceous carcinoma arising within a mature cystic teratoma of the ovary. Although the majority of cases originate from idiopathic mutations, there exists a strong association between this rare tumor and hereditary syndromes of DNA mismatch repair deficiency, such as Lynch syndrome and the lesser-known Muir-Torre syndrome. Here we present the case of a 67 year-old woman with a longstanding history of a small left ovarian cyst with sonographic features of an ovarian dermoid. After nine years, the left adnexal mass was noted to have enlarged, and she underwent a laparoscopic bilateral salpingo-oophorectomy. The final pathology was reported as sebaceous carcinoma arising within a mature cystic teratoma. The patient underwent subsequent surgical staging and has been followed for eight months without evidence of disease. This report includes a review of the current literature, as well as a brief discussion of the clinical management of women with sebaceous carcinoma arising within a mature teratoma. Additionally, we comment on the broader, hereditary significance of a diagnosis of sebaceous carcinoma, and use this case to demonstrate the thorough histologic and genetic evaluation that is recommended for patients diagnosed with this rare tumor. Keywords: Sebaceous carcinoma, Mature cystic teratoma, Dermoid cyst, Lynch syndrome, Muir-Torre syndrome, Hereditary nonpolyposis colorectal cancer (HNPCC)
url http://www.sciencedirect.com/science/article/pii/S2352578918300857
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