Genome-Wide Transcriptional Analysis Reveals the Protection against Hypoxia-Induced Oxidative Injury in the Intestine of Tibetans via the Inhibition of GRB2/EGFR/PTPN11 Pathways
The molecular mechanisms for hypoxic environment causing the injury of intestinal mucosal barrier (IMB) are widely unknown. To address the issue, Han Chinese from 100 m altitude and Tibetans from high altitude (more than 3650 m) were recruited. Histological and transcriptome analyses were performed....
Main Authors: | Kang Li, Luobu Gesang, Zeng Dan, Lamu Gusang |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2016-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2016/6967396 |
Similar Items
-
Whole-Genome Sequencing Identifies the Egl Nine Homologue 3 (egln3/phd3) and Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 (PPP1R2P1) Associated with High-Altitude Polycythemia in Tibetans at High Altitude
by: Luobu Gesang, et al.
Published: (2019-01-01) -
Transcriptome Reveals 1400-Fold Upregulation of APOA4-APOC3 and 1100-Fold Downregulation of GIF in the Patients with Polycythemia-Induced Gastric Injury.
by: Kang Li, et al.
Published: (2015-01-01) -
Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts
by: Ding Ding, et al.
Published: (2018-11-01) -
The regulatory role of PTPN23 on EGFR signaling
by: Chen, Yu-Fan, et al.
Published: (2013) -
Comparative Analysis of Gut Microbiota of Native Tibetan and Han Populations Living at Different Altitudes.
by: Kang Li, et al.
Published: (2016-01-01)