Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

We developed a highly stable recombinant human acidic fibroblast growth factor (rh-aFGF) carbomer 940 hydrogel for wound healing. This study aimed to reveal toxicity target organs and the toxicity dose-response in the long-term administration of rh-aFGF carbomer 940 hydrogel in a rabbit skin wound m...

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Bibliographic Details
Main Authors: Li Zhang, Tongzhou Huang, Jianing Bi, Yingying Zheng, Chao Lu, Qi Hui, Xiaojie Wang, Xiaohua Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
rh-aFGF
carbomer 940 hydrogel
long-term toxicity
immunotoxicity
neutralization antibody
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00058/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00058/full

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