Interleukin-1β Promotes Schwann Cells De-Differentiation in Wallerian Degeneration via the c-JUN/AP-1 Pathway

Interleukin-1β Promotes Schwann Cells De-Differentiation in Wallerian Degeneration via the c-JUN/AP-1 Pathway

Schwann cells (SCs) de-differentiate in Wallerian degeneration (WD) following nerve injury and, by doing so, can actively promote nerve repair and functional recovery. An innate-immune response is an important component of the complex of events referred to as WD. Damaged peripheral nervous system SC...

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Bibliographic Details
Main Authors: Gang Chen, Xiaohe Luo, Wenjin Wang, Yimei Wang, Fei Zhu, Wei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Wallerian degeneration
Schwann cells
IL-1β
MPZ
p75NTR
c-JUN/AP-1
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00304/full

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