Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in thetrans-to-cisisomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modification...

Full description

Bibliographic Details
Main Authors: Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, Scott A. Showalter
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15233

Similar Items

Similar Items