Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash

Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash

We report a case of a 29-year-old male who presented with paraesthesia and skin lesions with excessive bleeding after skin biopsy leading to hematology consultation. He was found to have prolonged partial thromboplastin time (PTT) and monoclonal gammopathy on serum protein electrophoresis (SPEP). He...

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Main Authors: S. Haider, T. Latif, A. Hochhausler, F. Lucas, N. Abdel Karim
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2013/890864
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spelling doaj-f4e2a4b0a4b24acc911239cff6d44b882020-11-24T23:18:07ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/890864890864Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and RashS. Haider0T. Latif1A. Hochhausler2F. Lucas3N. Abdel Karim4Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADepartment of Pathology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USADepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USAWe report a case of a 29-year-old male who presented with paraesthesia and skin lesions with excessive bleeding after skin biopsy leading to hematology consultation. He was found to have prolonged partial thromboplastin time (PTT) and monoclonal gammopathy on serum protein electrophoresis (SPEP). He experienced excessive bleeding leading to hospitalization after bone marrow biopsy and required blood transfusion. He was diagnosed with Waldenstrom's Macroglobulinemia (WM), based on the presence of IgM-κ type monoclonal (M) protein and infiltration of lymphoplasmacytic cells identified in bone marrow aspirates. He was noticed to have features of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS syndrome). This is a very rare case of WM with POEMS syndrome which responded to chemotherapy using bortezomib, steroids, and rituximab.http://dx.doi.org/10.1155/2013/890864
collection DOAJ
language English
format Article
sources DOAJ
author S. Haider
T. Latif
A. Hochhausler
F. Lucas
N. Abdel Karim
spellingShingle S. Haider
T. Latif
A. Hochhausler
F. Lucas
N. Abdel Karim
Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash
Case Reports in Oncological Medicine
author_facet S. Haider
T. Latif
A. Hochhausler
F. Lucas
N. Abdel Karim
author_sort S. Haider
title Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash
title_short Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash
title_full Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash
title_fullStr Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash
title_full_unstemmed Waldenstrom’s Macroglobulinemia and Peripheral Neuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes with a Bleeding Diathesis and Rash
title_sort waldenstrom’s macroglobulinemia and peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes with a bleeding diathesis and rash
publisher Hindawi Limited
series Case Reports in Oncological Medicine
issn 2090-6706
2090-6714
publishDate 2013-01-01
description We report a case of a 29-year-old male who presented with paraesthesia and skin lesions with excessive bleeding after skin biopsy leading to hematology consultation. He was found to have prolonged partial thromboplastin time (PTT) and monoclonal gammopathy on serum protein electrophoresis (SPEP). He experienced excessive bleeding leading to hospitalization after bone marrow biopsy and required blood transfusion. He was diagnosed with Waldenstrom's Macroglobulinemia (WM), based on the presence of IgM-κ type monoclonal (M) protein and infiltration of lymphoplasmacytic cells identified in bone marrow aspirates. He was noticed to have features of peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS syndrome). This is a very rare case of WM with POEMS syndrome which responded to chemotherapy using bortezomib, steroids, and rituximab.
url http://dx.doi.org/10.1155/2013/890864
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