Spectrophotometric investigation of famotidine-Pd(II) complex and its analytical application in drug analysis

• Main Authors: DRAGICA MINIC, JELENA PETKOVIC, TATIJANA JOVANOVIC, ZAGORKA KORICANAC
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2004-06-01
• Series: Journal of the Serbian Chemical Society
• Subjects: famotidine; palladium(II) chloride; complexometry; spectrophotometry; drug determination
• Online Access: http://www.shd.org.yu/HtDocs/SHD/Vol69/No6/V69-No6-08.pdf

By using different spectrophotometric methods, it was found that famotidine and palladium(II) ions form a complex, Pd(II) : famotidine = 1:1, which has an absorption maximum at 345 nm. The formation of the complex between famotidine and palladium(II) chloride in BrittonRobinson buffer solution in the pH range 2.238.50 was studied. The conditional stability constant of the complex at the optimum pH 2.62 and ionic strength 0.5 M was found to be log K = 3.742 ± 0.025. The Beers law was verified over the famotidine concentration range from 5×10-5 6×10-4 M. The proposed method was found to be suitable for accurate and sensitive analysis of famotidine both as the substance (RSD = 1.021.80 %) and its dosage forms (RSD = 1.751.83 %).