Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers

Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers

It is still a challenge for current nanopore sensing methods to differentiate multiple analytes from complex biological material. Here, the authors graft nucleic acid aptamer sequences along the backbone of a double stranded DNA carrier for the detection of multiple protein targets in human serum.

Bibliographic Details
Main Authors: Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Anthony E. G. Cass, Joshua B. Edel
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01584-3
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spelling doaj-f4d9252357194915982ab31463cf732e2021-05-11T07:38:50ZengNature Publishing GroupNature Communications2041-17232017-11-018111010.1038/s41467-017-01584-3Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriersJasmine Y. Y. Sze0Aleksandar P. Ivanov1Anthony E. G. Cass2Joshua B. Edel3Department of Chemistry, Imperial College LondonDepartment of Chemistry, Imperial College LondonDepartment of Chemistry, Imperial College LondonDepartment of Chemistry, Imperial College LondonIt is still a challenge for current nanopore sensing methods to differentiate multiple analytes from complex biological material. Here, the authors graft nucleic acid aptamer sequences along the backbone of a double stranded DNA carrier for the detection of multiple protein targets in human serum.https://doi.org/10.1038/s41467-017-01584-3
collection DOAJ
language English
format Article
sources DOAJ
author Jasmine Y. Y. Sze
Aleksandar P. Ivanov
Anthony E. G. Cass
Joshua B. Edel
spellingShingle Jasmine Y. Y. Sze
Aleksandar P. Ivanov
Anthony E. G. Cass
Joshua B. Edel
Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers
Nature Communications
author_facet Jasmine Y. Y. Sze
Aleksandar P. Ivanov
Anthony E. G. Cass
Joshua B. Edel
author_sort Jasmine Y. Y. Sze
title Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers
title_short Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers
title_full Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers
title_fullStr Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers
title_full_unstemmed Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers
title_sort single molecule multiplexed nanopore protein screening in human serum using aptamer modified dna carriers
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description It is still a challenge for current nanopore sensing methods to differentiate multiple analytes from complex biological material. Here, the authors graft nucleic acid aptamer sequences along the backbone of a double stranded DNA carrier for the detection of multiple protein targets in human serum.
url https://doi.org/10.1038/s41467-017-01584-3
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AT anthonyegcass singlemoleculemultiplexednanoporeproteinscreeninginhumanserumusingaptamermodifieddnacarriers
AT joshuabedel singlemoleculemultiplexednanoporeproteinscreeninginhumanserumusingaptamermodifieddnacarriers
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