Inferring the number and position of changes in selective regime in a non-equilibrium mutation-selection framework

Inferring the number and position of changes in selective regime in a non-equilibrium mutation-selection framework

Abstract Background Recovering the historical patterns of selection acting on a protein coding sequence is a major goal of evolutionary biology. Mutation-selection models address this problem by explicitly modelling fixation rates as a function of site-specific amino acid fitness values.However, the...

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Bibliographic Details
Main Authors: Andrew M. Ritchie, Tristan L. Stark, David A. Liberles
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Ecology and Evolution
Subjects:
Mutation-selection model
Positive selection
Stationarity
Phylogenetic methods
Online Access:https://doi.org/10.1186/s12862-021-01770-4

Internet

https://doi.org/10.1186/s12862-021-01770-4

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