Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives

Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxyla...

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Main Authors: Ionuţ Ledeţi, Ştefana Avram, Vasile Bercean, Gabriela Vlase, Titus Vlase, Adriana Ledeţi, Istvan Zupko, Marius Mioc, Lenuţa-Maria Şuta, Codruţa Şoica, Cristina Dehelean
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
betulonic acid derivatives
triterpene
thermal analysis
synthesis
biological activity
MTT assay
Online Access:http://www.mdpi.com/1420-3049/20/12/19876
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spelling doaj-f4d698d484ff4c7a977808e9af99b24f2020-11-24T21:47:08ZengMDPI AGMolecules1420-30492015-12-012012226912270210.3390/molecules201219876molecules201219876Solid-State Characterization and Biological Activity of Betulonic Acid DerivativesIonuţ Ledeţi0Ştefana Avram1Vasile Bercean2Gabriela Vlase3Titus Vlase4Adriana Ledeţi5Istvan Zupko6Marius Mioc7Lenuţa-Maria Şuta8Codruţa Şoica9Cristina Dehelean10Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, RomaniaFaculty of Industrial Chemistry and Environmental Engineering, Politehnica University Timişoara, 6 Carol Telbisz, 300001 Timisoara, RomaniaResearch Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, RomaniaResearch Centre for Thermal Analysis in Environmental Problems, West University of Timişoara, 300115 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, RomaniaDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, 6 Eotvos Str., H-6720 Szeged, HungaryFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, RomaniaFaculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, RomaniaBetulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.http://www.mdpi.com/1420-3049/20/12/19876betulonic acid derivativestriterpenethermal analysissynthesisbiological activityMTT assay
collection DOAJ
language English
format Article
sources DOAJ
author Ionuţ Ledeţi
Ştefana Avram
Vasile Bercean
Gabriela Vlase
Titus Vlase
Adriana Ledeţi
Istvan Zupko
Marius Mioc
Lenuţa-Maria Şuta
Codruţa Şoica
Cristina Dehelean
spellingShingle Ionuţ Ledeţi
Ştefana Avram
Vasile Bercean
Gabriela Vlase
Titus Vlase
Adriana Ledeţi
Istvan Zupko
Marius Mioc
Lenuţa-Maria Şuta
Codruţa Şoica
Cristina Dehelean
Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
Molecules
betulonic acid derivatives
triterpene
thermal analysis
synthesis
biological activity
MTT assay
author_facet Ionuţ Ledeţi
Ştefana Avram
Vasile Bercean
Gabriela Vlase
Titus Vlase
Adriana Ledeţi
Istvan Zupko
Marius Mioc
Lenuţa-Maria Şuta
Codruţa Şoica
Cristina Dehelean
author_sort Ionuţ Ledeţi
title Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
title_short Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
title_full Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
title_fullStr Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
title_full_unstemmed Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
title_sort solid-state characterization and biological activity of betulonic acid derivatives
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2015-12-01
description Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.
topic betulonic acid derivatives
triterpene
thermal analysis
synthesis
biological activity
MTT assay
url http://www.mdpi.com/1420-3049/20/12/19876
work_keys_str_mv AT ionutledeti solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT stefanaavram solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT vasilebercean solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT gabrielavlase solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT titusvlase solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT adrianaledeti solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT istvanzupko solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT mariusmioc solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT lenutamariasuta solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT codrutasoica solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
AT cristinadehelean solidstatecharacterizationandbiologicalactivityofbetulonicacidderivatives
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