Blockade of NF-κB Translocation and of RANKL/RANK Interaction Decreases the Frequency of Th2 and Th17 Cells Capable of IL-4 and IL-17 Production, Respectively, in a Mouse Model of Allergic Asthma

Blockade of NF-κB Translocation and of RANKL/RANK Interaction Decreases the Frequency of Th2 and Th17 Cells Capable of IL-4 and IL-17 Production, Respectively, in a Mouse Model of Allergic Asthma

The main purpose of this study was to investigate whether the blockade of the interaction between the receptor activator of nuclear factor-κB (NF-ĸB) ligand (RANKL) and its receptor RANK as well as the blockade of NF-κB inhibitor kinase (IKK) and of NF-κB translocation have the potential to suppress...

Full description

Bibliographic Details
Main Authors: Izabela Gregorczyk, Agnieszka Jasiecka-Mikołajczyk, Tomasz Maślanka
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
allergic asthma
NF-κB and RANKL/RANK/OPG pathways
cytokines
Online Access:https://www.mdpi.com/1420-3049/26/11/3117

Similar Items

Similar Items