Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy

Promethazine and scopolamine are two major components of a drug commonly used as a substitute for heroin addiction but with its own potential for abuse. Here, surface-enhanced Raman spectroscopy experiments were combined with density functional theory computations of the Raman frequencies of prometh...

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Main Authors:	Lin Bao, Siqingaowa Han, Xuanyu Sha, Hang Zhao, Yuping Liu, Dianyang Lin, Wuliji Hasi
Format:	Article
Language:	English
Published:	Hindawi Limited 2019-01-01
Series:	Journal of Spectroscopy
Online Access:	http://dx.doi.org/10.1155/2019/7458371

id	doaj-f4d0764857bf47baa62784e9fd52c21d
record_format	Article
spelling	doaj-f4d0764857bf47baa62784e9fd52c21d2020-11-25T01:23:25ZengHindawi LimitedJournal of Spectroscopy2314-49202314-49392019-01-01201910.1155/2019/74583717458371Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman SpectroscopyLin Bao0Siqingaowa Han1Xuanyu Sha2Hang Zhao3Yuping Liu4Dianyang Lin5Wuliji Hasi6National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, ChinaAffiliated Hospital, Inner Mongolia University for the Nationalities, Inner Mongolia, Tongliao 028007, ChinaNational Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, ChinaNational Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, ChinaNational Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, ChinaNational Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, ChinaNational Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, ChinaPromethazine and scopolamine are two major components of a drug commonly used as a substitute for heroin addiction but with its own potential for abuse. Here, surface-enhanced Raman spectroscopy experiments were combined with density functional theory computations of the Raman frequencies of promethazine. The enhancement of the SERS substrate was optimized by contrast detection of silver nanoparticles. The optimized substrate was used to detect scopolamine, promethazine and their mixtures. Several mixtures of different concentrations were detected and analyzed. The approach of rapid identification and monitoring of drugs will become an important tool in the detection and control of illicit drug use.http://dx.doi.org/10.1155/2019/7458371
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lin Bao Siqingaowa Han Xuanyu Sha Hang Zhao Yuping Liu Dianyang Lin Wuliji Hasi
spellingShingle	Lin Bao Siqingaowa Han Xuanyu Sha Hang Zhao Yuping Liu Dianyang Lin Wuliji Hasi Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy Journal of Spectroscopy
author_facet	Lin Bao Siqingaowa Han Xuanyu Sha Hang Zhao Yuping Liu Dianyang Lin Wuliji Hasi
author_sort	Lin Bao
title	Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy
title_short	Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy
title_full	Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy
title_fullStr	Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy
title_full_unstemmed	Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy
title_sort	detection of alternative drugs for illegal injection based on surface-enhanced raman spectroscopy
publisher	Hindawi Limited
series	Journal of Spectroscopy
issn	2314-4920 2314-4939
publishDate	2019-01-01
description	Promethazine and scopolamine are two major components of a drug commonly used as a substitute for heroin addiction but with its own potential for abuse. Here, surface-enhanced Raman spectroscopy experiments were combined with density functional theory computations of the Raman frequencies of promethazine. The enhancement of the SERS substrate was optimized by contrast detection of silver nanoparticles. The optimized substrate was used to detect scopolamine, promethazine and their mixtures. Several mixtures of different concentrations were detected and analyzed. The approach of rapid identification and monitoring of drugs will become an important tool in the detection and control of illicit drug use.
url	http://dx.doi.org/10.1155/2019/7458371
work_keys_str_mv	AT linbao detectionofalternativedrugsforillegalinjectionbasedonsurfaceenhancedramanspectroscopy AT siqingaowahan detectionofalternativedrugsforillegalinjectionbasedonsurfaceenhancedramanspectroscopy AT xuanyusha detectionofalternativedrugsforillegalinjectionbasedonsurfaceenhancedramanspectroscopy AT hangzhao detectionofalternativedrugsforillegalinjectionbasedonsurfaceenhancedramanspectroscopy AT yupingliu detectionofalternativedrugsforillegalinjectionbasedonsurfaceenhancedramanspectroscopy AT dianyanglin detectionofalternativedrugsforillegalinjectionbasedonsurfaceenhancedramanspectroscopy AT wulijihasi detectionofalternativedrugsforillegalinjectionbasedonsurfaceenhancedramanspectroscopy
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Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy

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