Detection of Alternative Drugs for Illegal Injection Based on Surface-Enhanced Raman Spectroscopy

Promethazine and scopolamine are two major components of a drug commonly used as a substitute for heroin addiction but with its own potential for abuse. Here, surface-enhanced Raman spectroscopy experiments were combined with density functional theory computations of the Raman frequencies of prometh...

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Bibliographic Details
Main Authors: Lin Bao, Siqingaowa Han, Xuanyu Sha, Hang Zhao, Yuping Liu, Dianyang Lin, Wuliji Hasi
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Spectroscopy
Online Access:http://dx.doi.org/10.1155/2019/7458371
Description
Summary:Promethazine and scopolamine are two major components of a drug commonly used as a substitute for heroin addiction but with its own potential for abuse. Here, surface-enhanced Raman spectroscopy experiments were combined with density functional theory computations of the Raman frequencies of promethazine. The enhancement of the SERS substrate was optimized by contrast detection of silver nanoparticles. The optimized substrate was used to detect scopolamine, promethazine and their mixtures. Several mixtures of different concentrations were detected and analyzed. The approach of rapid identification and monitoring of drugs will become an important tool in the detection and control of illicit drug use.
ISSN:2314-4920
2314-4939