Macrophage-specific chemokines induced via innate immunity by amino acid copolymers and their role in EAE.

Macrophage-specific chemokines induced via innate immunity by amino acid copolymers and their role in EAE.

The random amino acid copolymer poly(Y,E,A,K)(n) (Copaxone®) is widely used in multiple sclerosis treatment and a second generation copolymer poly(Y,F,A,K)(n) with enhanced efficacy in experimental autoimmune encephalomyelitis in mice has been described. A major mechanism through which copolymers fu...

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Bibliographic Details
Main Authors: Joseph Kovalchin, Jeffrey Krieger, Michelle Genova, Norio Kawamoto, Michael Augustyniak, Kathryn Collins, Troy Bloom, Allyson Masci, Tara Hittinger, Ingrid Dufour, Jack L Strominger, Eric Zanelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3240613?pdf=render

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