Preoperative Aspirin Management in Redo Tetralogy of Fallot Population: Single Centre Experience

• Main Authors: Giuseppe Comentale, Gaetano Palma, Valentina Parisi, Silvio Simeone, Gianluca Pucciarelli, Rachele Manzo, Emanuele Pilato, Raffaele Giordano
• Format: Article
• Language: English
• Published: MDPI AG 2020-11-01
• Series: Healthcare
• Subjects: aspirin; redo congenital heart patients; Tetralogy of Fallot; RVOT
• Online Access: https://www.mdpi.com/2227-9032/8/4/455

<i>Purpose</i>: Redo operations and preoperative antiplatelet/anticoagulant therapy can significantly increase surgical risk in congenital heart surgery. This is a retrospective study on the impact of preoperative aspirin therapy on the outcome of Tetralogy of Redo Fallot patients undergoing right ventricle outflow tract (RVOT) conduit implantation. <i>Methods</i>: Ten-years retrospective analysis of medical records was carried out. A total of 72 patients were divided into two groups: “Daily-on-ASA” group on daily therapy with aspirin (ASA) until 5 days from surgery and “No-Home-ASA” without it. Propensity match analysis was done in order to standardize the populations. Intraoperative and postoperative lengths were compared as well as the need for inotropic support. In addition, differences in blood transfusions and need for Fresh frozen plasma (FFP)/platelets (PLT) were analysed. <i>Findings</i>: Intraoperative lengths were similar between the groups. Not statistically significative differences about postoperative time to extubation (<i>p</i> = 0.34), ICU Stay (<i>p</i> = 0.31) or in-hospital stay (<i>p</i> = 0.36) were found. Drain loss was higher in the “Daily-on-ASA” group (407.9 ± 96.7 mL vs. 349.5 ± 84.3 mL; <i>p</i> = 0.03) as well as blood transfusions (372.7 ± 255.1 mL vs. 220.1 ± 130.3 mL, <i>p</i> = 0.02) and PLT/FFP need (217.7 ± 132.1 mL vs. 118.7 ± 147.1 mL, <i>p</i> = 0.01). No differences were found in postoperative complications or re-explorations for bleeding. <i>Implications</i>: We found no advantages in surgical times and hospital stay comparing redo patients who stopped aspirin versus those that didn’t take it in the last 6 months. However, our results suggest that redo patients undergoing RVOT conduit implantation who take daily aspirin are at higher risk of bleeding even if it is stopped 5 days before surgery.