Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others

Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others

Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulat...

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Main Authors: Liwen Wang, Jinhan Wang, Lianying Fang, Zuliang Zheng, Dexian Zhi, Suying Wang, Shiming Li, Chi-Tang Ho, Hui Zhao
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/453972
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spelling doaj-f4c945cdb325483d96525b1baf0a94af2020-11-24T22:12:46ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/453972453972Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and OthersLiwen Wang0Jinhan Wang1Lianying Fang2Zuliang Zheng3Dexian Zhi4Suying Wang5Shiming Li6Chi-Tang Ho7Hui Zhao8Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaTianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaTianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaTianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaTianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaTianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang, Hubei 438000, ChinaDepartment of Food Science, Rutgers University, New Brunswick, NJ 08901-8502, USATianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaCitrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in vivo studies indicate protective effects of polymethoxyflavones (PMFs) against the occurrence of cancer. PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis. This review systematically summarized anticarcinogenic effect of citrus flavonoids in cancer therapy, together with the underlying important molecular mechanisms, in purpose of further exploring more effective use of citrus peel flavonoids.http://dx.doi.org/10.1155/2014/453972
collection DOAJ
language English
format Article
sources DOAJ
author Liwen Wang
Jinhan Wang
Lianying Fang
Zuliang Zheng
Dexian Zhi
Suying Wang
Shiming Li
Chi-Tang Ho
Hui Zhao
spellingShingle Liwen Wang
Jinhan Wang
Lianying Fang
Zuliang Zheng
Dexian Zhi
Suying Wang
Shiming Li
Chi-Tang Ho
Hui Zhao
Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
BioMed Research International
author_facet Liwen Wang
Jinhan Wang
Lianying Fang
Zuliang Zheng
Dexian Zhi
Suying Wang
Shiming Li
Chi-Tang Ho
Hui Zhao
author_sort Liwen Wang
title Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
title_short Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
title_full Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
title_fullStr Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
title_full_unstemmed Anticancer Activities of Citrus Peel Polymethoxyflavones Related to Angiogenesis and Others
title_sort anticancer activities of citrus peel polymethoxyflavones related to angiogenesis and others
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in vivo studies indicate protective effects of polymethoxyflavones (PMFs) against the occurrence of cancer. PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis. This review systematically summarized anticarcinogenic effect of citrus flavonoids in cancer therapy, together with the underlying important molecular mechanisms, in purpose of further exploring more effective use of citrus peel flavonoids.
url http://dx.doi.org/10.1155/2014/453972
work_keys_str_mv AT liwenwang anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT jinhanwang anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT lianyingfang anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT zuliangzheng anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT dexianzhi anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT suyingwang anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT shimingli anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT chitangho anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
AT huizhao anticanceractivitiesofcitruspeelpolymethoxyflavonesrelatedtoangiogenesisandothers
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