Structural basis for inhibition of the MDM2:p53 interaction by an optimized MDM2-binding peptide selected with mRNA display.

Structural basis for inhibition of the MDM2:p53 interaction by an optimized MDM2-binding peptide selected with mRNA display.

The oncoprotein MDM2 binds to tumor suppressor protein p53 and inhibits its anticancer activity, which leads to promotion of tumor cell growth and tumor survival. Abrogation of the p53:MDM2 interaction reportedly results in reactivation of the p53 pathway and inhibition of tumor cell proliferation....

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Bibliographic Details
Main Authors: Takashi Nagata, Kie Shirakawa, Naohiro Kobayashi, Hirokazu Shiheido, Noriko Tabata, Yuko Sakuma-Yonemura, Kenichi Horisawa, Masato Katahira, Nobuhide Doi, Hiroshi Yanagawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4183577?pdf=render

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