Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis

Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis

While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 and RNA helicase Ddx5/17 to control mRNA decay.

Bibliographic Details
Main Authors: Byoung-San Moon, Jinlun Bai, Mingyang Cai, Chunming Liu, Jiandang Shi, Wange Lu
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02720-9
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spelling doaj-f4bb66914ce74744b74376ccdc9f2c052021-05-11T10:09:50ZengNature Publishing GroupNature Communications2041-17232018-01-019111510.1038/s41467-017-02720-9Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesisByoung-San Moon0Jinlun Bai1Mingyang Cai2Chunming Liu3Jiandang Shi4Wange Lu5Department of Stem Cell Biology and Regenerative Medicine, Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern CaliforniaDepartment of Stem Cell Biology and Regenerative Medicine, Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern CaliforniaDepartment of Stem Cell Biology and Regenerative Medicine, Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern CaliforniaDepartment of Molecular and Cellular Biochemistry, University of KentuckyState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai UniversityDepartment of Stem Cell Biology and Regenerative Medicine, Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern CaliforniaWhile being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 and RNA helicase Ddx5/17 to control mRNA decay.https://doi.org/10.1038/s41467-017-02720-9
collection DOAJ
language English
format Article
sources DOAJ
author Byoung-San Moon
Jinlun Bai
Mingyang Cai
Chunming Liu
Jiandang Shi
Wange Lu
spellingShingle Byoung-San Moon
Jinlun Bai
Mingyang Cai
Chunming Liu
Jiandang Shi
Wange Lu
Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
Nature Communications
author_facet Byoung-San Moon
Jinlun Bai
Mingyang Cai
Chunming Liu
Jiandang Shi
Wange Lu
author_sort Byoung-San Moon
title Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_short Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_full Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_fullStr Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_full_unstemmed Kruppel-like factor 4-dependent Staufen1-mediated mRNA decay regulates cortical neurogenesis
title_sort kruppel-like factor 4-dependent staufen1-mediated mrna decay regulates cortical neurogenesis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description While being known as a transcription factor, Kruppel-like factor 4 (Klf4) may have other molecular functions. This study shows that Klf4 in neural progenitor cells regulate neurogenesis and self-renewal by interacting with RNA-binding protein Staufen1 and RNA helicase Ddx5/17 to control mRNA decay.
url https://doi.org/10.1038/s41467-017-02720-9
work_keys_str_mv AT byoungsanmoon kruppellikefactor4dependentstaufen1mediatedmrnadecayregulatescorticalneurogenesis
AT jinlunbai kruppellikefactor4dependentstaufen1mediatedmrnadecayregulatescorticalneurogenesis
AT mingyangcai kruppellikefactor4dependentstaufen1mediatedmrnadecayregulatescorticalneurogenesis
AT chunmingliu kruppellikefactor4dependentstaufen1mediatedmrnadecayregulatescorticalneurogenesis
AT jiandangshi kruppellikefactor4dependentstaufen1mediatedmrnadecayregulatescorticalneurogenesis
AT wangelu kruppellikefactor4dependentstaufen1mediatedmrnadecayregulatescorticalneurogenesis
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