EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR
Peripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. Three monoclonal antibodies (anti-CD3, anti CD-f, unti-CDS) were simultaneously applied for detection of Th (CD3-, CD4^...
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Tehran University of Medical Sciences
1999-07-01
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| Series: | Acta Medica Iranica |
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| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4849.pdf&manuscript_id=4849 |
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doaj-f4b9b2a90f344ace855be7123e97cde52020-11-25T03:04:11ZengTehran University of Medical SciencesActa Medica Iranica0044-60251999-07-013727377EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJORA. DaneshM. Mir-AhmadianPeripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. Three monoclonal antibodies (anti-CD3, anti CD-f, unti-CDS) were simultaneously applied for detection of Th (CD3-, CD4^), Tsk (CD3+, CD8+) and Th/Ts ratio by flow-cytometry respectively. The results of this study showed a slight increase in the number of Tlymphocytes, T 004^, TCDS+, and CD4'*/CDS* ratio; but this increase was not statistically significant (P>0.05). No primary defect in Tcell subsets was detected and it was suggested that continuous regulation of iron balance is an important factor in decreasing immunological disturbance.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4849.pdf&manuscript_id=4849Beta thalassemia majorT cell subsets |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
A. Danesh M. Mir-Ahmadian |
| spellingShingle |
A. Danesh M. Mir-Ahmadian EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR Acta Medica Iranica Beta thalassemia major T cell subsets |
| author_facet |
A. Danesh M. Mir-Ahmadian |
| author_sort |
A. Danesh |
| title |
EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_short |
EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_full |
EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_fullStr |
EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_full_unstemmed |
EVALUATION OF T LYMPHOCYTE SUBSETS IN CHILDREN WITH BETA THALASSEMIA MAJOR |
| title_sort |
evaluation of t lymphocyte subsets in children with beta thalassemia major |
| publisher |
Tehran University of Medical Sciences |
| series |
Acta Medica Iranica |
| issn |
0044-6025 |
| publishDate |
1999-07-01 |
| description |
Peripheral blood T lymphocytes and their subsets were studied in 31 patients with beta thalassemia major (age 2-12years) and compared with 14 age-arid sex-matched healthy controls. Three monoclonal antibodies (anti-CD3, anti CD-f, unti-CDS) were simultaneously applied for detection of Th (CD3-, CD4^), Tsk (CD3+, CD8+) and Th/Ts ratio by flow-cytometry respectively. The results of this study showed a slight increase in the number of Tlymphocytes, T 004^, TCDS+, and CD4'*/CDS* ratio; but this increase was not statistically significant (P>0.05). No primary defect in Tcell subsets was detected and it was suggested that continuous regulation of iron balance is an important factor in decreasing immunological disturbance. |
| topic |
Beta thalassemia major T cell subsets |
| url |
http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4849.pdf&manuscript_id=4849 |
| work_keys_str_mv |
AT adanesh evaluationoftlymphocytesubsetsinchildrenwithbetathalassemiamajor AT mmirahmadian evaluationoftlymphocytesubsetsinchildrenwithbetathalassemiamajor |
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