DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis

DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) has been linked to chronic lung inflammation. Drosha ribonuclease III (DROSHA), a class 2 ribonuclease III enzyme, plays a key role in microRNA (miRNA) biogenesis. However, the mechanisms by which DROSHA affects the lung inflammation during idiopathic pulmonary fi...

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Bibliographic Details
Main Authors: Soo Jung Cho, Kyoung Sook Hong, Ji Hun Jeong, Mihye Lee, Augustine M. K. Choi, Heather W. Stout-Delgado, Jong-Seok Moon
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
DROSHA
miRNA
AIM2 inflammasome
idiopathic pulmonary fibrosis
Online Access:https://www.mdpi.com/2073-4409/8/8/938

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