Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis

Objectives To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.Data sources PubMed, Web of Science and Embase were searched for eligible studies up to September 2020.Study selection Cohort studies were...

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Main Authors: Xiaonan Chen, Yiqiao Zhao, Zijia Tao, Kefeng Wang
Format: Article
Language:English
Published: BMJ Publishing Group 2021-02-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/11/2/e038902.full
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spelling doaj-f4ad7e1b9841477089cbb5179cd230d92021-06-25T13:30:11ZengBMJ Publishing GroupBMJ Open2044-60552021-02-0111210.1136/bmjopen-2020-038902Coffee consumption and risk of prostate cancer: a systematic review and meta-analysisXiaonan Chen0Yiqiao Zhao1Zijia Tao2Kefeng Wang3Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, ChinaObjectives To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.Data sources PubMed, Web of Science and Embase were searched for eligible studies up to September 2020.Study selection Cohort studies were included.Data extraction and synthesis Two researchers independently reviewed the studies and extracted the data. Data synthesis was performed via systematic review and meta-analysis of eligible cohort studies. Meta-analysis was performed with the “metan” and “glst” commands in Stata 14.0.Main outcomes and measures Prostate cancer was the main outcome. It was classified as localised prostate cancer which included localised or non-aggressive cancers; advanced prostate cancer which included advanced or aggressive cancers; or fatal prostate cancer which included fatal/lethal cancers or prostate cancer-specific deaths.Results Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative risk (RR) was 0.91 (95% CI 0.84 to 0.98), I2= 53.2%) for the highest category of coffee consumption. There was a significant linear trend for the association (p=0.006 for linear trend), with a pooled RR of 0.988 (95% CI 0.981 to 0.995) for each increment of one cup of coffee per day. For localised, advanced and fatal prostate cancer, the pooled RRs were 0.93 (95% CI 0.87 to 0.99), 0.88 (95% CI 0.71 to 1.09) and 0.84 (95% CI 0.66 to 1.08), respectively. No evidence of publication bias was indicated in this meta-analysis.Conclusions This study suggests that a higher intake of coffee may be associated with a lower risk of prostate cancer.https://bmjopen.bmj.com/content/11/2/e038902.full
collection DOAJ
language English
format Article
sources DOAJ
author Xiaonan Chen
Yiqiao Zhao
Zijia Tao
Kefeng Wang
spellingShingle Xiaonan Chen
Yiqiao Zhao
Zijia Tao
Kefeng Wang
Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis
BMJ Open
author_facet Xiaonan Chen
Yiqiao Zhao
Zijia Tao
Kefeng Wang
author_sort Xiaonan Chen
title Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis
title_short Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis
title_full Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis
title_fullStr Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis
title_full_unstemmed Coffee consumption and risk of prostate cancer: a systematic review and meta-analysis
title_sort coffee consumption and risk of prostate cancer: a systematic review and meta-analysis
publisher BMJ Publishing Group
series BMJ Open
issn 2044-6055
publishDate 2021-02-01
description Objectives To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.Data sources PubMed, Web of Science and Embase were searched for eligible studies up to September 2020.Study selection Cohort studies were included.Data extraction and synthesis Two researchers independently reviewed the studies and extracted the data. Data synthesis was performed via systematic review and meta-analysis of eligible cohort studies. Meta-analysis was performed with the “metan” and “glst” commands in Stata 14.0.Main outcomes and measures Prostate cancer was the main outcome. It was classified as localised prostate cancer which included localised or non-aggressive cancers; advanced prostate cancer which included advanced or aggressive cancers; or fatal prostate cancer which included fatal/lethal cancers or prostate cancer-specific deaths.Results Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative risk (RR) was 0.91 (95% CI 0.84 to 0.98), I2= 53.2%) for the highest category of coffee consumption. There was a significant linear trend for the association (p=0.006 for linear trend), with a pooled RR of 0.988 (95% CI 0.981 to 0.995) for each increment of one cup of coffee per day. For localised, advanced and fatal prostate cancer, the pooled RRs were 0.93 (95% CI 0.87 to 0.99), 0.88 (95% CI 0.71 to 1.09) and 0.84 (95% CI 0.66 to 1.08), respectively. No evidence of publication bias was indicated in this meta-analysis.Conclusions This study suggests that a higher intake of coffee may be associated with a lower risk of prostate cancer.
url https://bmjopen.bmj.com/content/11/2/e038902.full
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AT yiqiaozhao coffeeconsumptionandriskofprostatecancerasystematicreviewandmetaanalysis
AT zijiatao coffeeconsumptionandriskofprostatecancerasystematicreviewandmetaanalysis
AT kefengwang coffeeconsumptionandriskofprostatecancerasystematicreviewandmetaanalysis
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