How Diffusion Impacts Cortical Protein Distribution in Yeasts

How Diffusion Impacts Cortical Protein Distribution in Yeasts

Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achiev...

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Bibliographic Details
Main Authors: Kyle D. Moran, Daniel J. Lew
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
diffusion
cell polarity
Cdc42
Online Access:https://www.mdpi.com/2073-4409/9/5/1113
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spelling doaj-f4a229168417408dabc67218efe6320d2020-11-25T03:29:29ZengMDPI AGCells2073-44092020-04-0191113111310.3390/cells9051113How Diffusion Impacts Cortical Protein Distribution in YeastsKyle D. Moran0Daniel J. Lew1Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USADepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USAProteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions of membrane proteins despite the anticipated dissipative effects of diffusion, and highlight recent findings suggesting that differential diffusion is exploited to create, rather than dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma membranes that remain unsolved.https://www.mdpi.com/2073-4409/9/5/1113diffusioncell polarityCdc42
collection DOAJ
language English
format Article
sources DOAJ
author Kyle D. Moran
Daniel J. Lew
spellingShingle Kyle D. Moran
Daniel J. Lew
How Diffusion Impacts Cortical Protein Distribution in Yeasts
Cells
diffusion
cell polarity
Cdc42
author_facet Kyle D. Moran
Daniel J. Lew
author_sort Kyle D. Moran
title How Diffusion Impacts Cortical Protein Distribution in Yeasts
title_short How Diffusion Impacts Cortical Protein Distribution in Yeasts
title_full How Diffusion Impacts Cortical Protein Distribution in Yeasts
title_fullStr How Diffusion Impacts Cortical Protein Distribution in Yeasts
title_full_unstemmed How Diffusion Impacts Cortical Protein Distribution in Yeasts
title_sort how diffusion impacts cortical protein distribution in yeasts
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-04-01
description Proteins associated with the yeast plasma membrane often accumulate asymmetrically within the plane of the membrane. Asymmetric accumulation is thought to underlie diverse processes, including polarized growth, stress sensing, and aging. Here, we review our evolving understanding of how cells achieve asymmetric distributions of membrane proteins despite the anticipated dissipative effects of diffusion, and highlight recent findings suggesting that differential diffusion is exploited to create, rather than dissipate, asymmetry. We also highlight open questions about diffusion in yeast plasma membranes that remain unsolved.
topic diffusion
cell polarity
Cdc42
url https://www.mdpi.com/2073-4409/9/5/1113
work_keys_str_mv AT kyledmoran howdiffusionimpactscorticalproteindistributioninyeasts
AT danieljlew howdiffusionimpactscorticalproteindistributioninyeasts
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