Membrane-Type 1 Matrix Metal loproteinase Is Regulated by Sp1 through the Differential Activation of AKT, JNK, and ERK Pathways in Human Prostate Tumor Cells

Membrane-Type 1 Matrix Metal loproteinase Is Regulated by Sp1 through the Differential Activation of AKT, JNK, and ERK Pathways in Human Prostate Tumor Cells

We and other investigators have previously shown that membrane-type 1 matrix metalloproteinase (MT1-MMP) is overexpressed in invasive prostate cancer cells. However, the mechanism for this expression is not known. Here, we show that MT1-MMP is minimally expressed in nonmalignant primary prostate ce...

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Bibliographic Details
Main Authors: Isis C. Sroka, Raymond B. Nagle, G. Tim Bowden
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
MT1-MMP
Sp1
AKT MAP kinases
prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800911

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