Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from Nɛ-acetyl lysine. In the current study, we raised a novel design, which concerns Nɛ-acetyl lysine derivatives containi...

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Main Authors: Fang Wang, Chun Wang, Jie Wang, Yefang Zou, Xiaoxue Chen, Ting Liu, Yan Li, Yonglong Zhao, Yongjun Li, Bin He
Format: Article
Language:English
Published: The Royal Society 2019-06-01
Series:Royal Society Open Science
Subjects:
nɛ-acetyl lysine
zbg group
analogues
hybridization
hdac inhibitor
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.190338
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spelling doaj-f493a2bb0afd4a09b70b28c7cfe57dbb2020-11-25T04:02:57ZengThe Royal SocietyRoyal Society Open Science2054-57032019-06-016610.1098/rsos.190338190338Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitorsFang WangChun WangJie WangYefang ZouXiaoxue ChenTing LiuYan LiYonglong ZhaoYongjun LiBin HeHDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from Nɛ-acetyl lysine. In the current study, we raised a novel design, which concerns Nɛ-acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.190338nɛ-acetyl lysinezbg groupanalogueshybridizationhdac inhibitor
collection DOAJ
language English
format Article
sources DOAJ
author Fang Wang
Chun Wang
Jie Wang
Yefang Zou
Xiaoxue Chen
Ting Liu
Yan Li
Yonglong Zhao
Yongjun Li
Bin He
spellingShingle Fang Wang
Chun Wang
Jie Wang
Yefang Zou
Xiaoxue Chen
Ting Liu
Yan Li
Yonglong Zhao
Yongjun Li
Bin He
Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
Royal Society Open Science
nɛ-acetyl lysine
zbg group
analogues
hybridization
hdac inhibitor
author_facet Fang Wang
Chun Wang
Jie Wang
Yefang Zou
Xiaoxue Chen
Ting Liu
Yan Li
Yonglong Zhao
Yongjun Li
Bin He
author_sort Fang Wang
title Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
title_short Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
title_full Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
title_fullStr Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
title_full_unstemmed Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
title_sort nɛ-acetyl lysine derivatives with zinc binding groups as novel hdac inhibitors
publisher The Royal Society
series Royal Society Open Science
issn 2054-5703
publishDate 2019-06-01
description HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from Nɛ-acetyl lysine. In the current study, we raised a novel design, which concerns Nɛ-acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.
topic nɛ-acetyl lysine
zbg group
analogues
hybridization
hdac inhibitor
url https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.190338
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AT chunwang nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT jiewang nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT yefangzou nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT xiaoxuechen nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT tingliu nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT yanli nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT yonglongzhao nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT yongjunli nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
AT binhe nɛacetyllysinederivativeswithzincbindinggroupsasnovelhdacinhibitors
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