Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from Nɛ-acetyl lysine. In the current study, we raised a novel design, which concerns Nɛ-acetyl lysine derivatives containi...

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Bibliographic Details
Main Authors: Fang Wang, Chun Wang, Jie Wang, Yefang Zou, Xiaoxue Chen, Ting Liu, Yan Li, Yonglong Zhao, Yongjun Li, Bin He
Format: Article
Language:English
Published: The Royal Society 2019-06-01
Series:Royal Society Open Science
Subjects:
nɛ-acetyl lysine
zbg group
analogues
hybridization
hdac inhibitor
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.190338
Description
Summary:HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from Nɛ-acetyl lysine. In the current study, we raised a novel design, which concerns Nɛ-acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.
ISSN:2054-5703

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