Состояние фетоплацентарной системы у беременных с недифференцированными формами дисплазии соединительной ткани, носителей семейства герпес-вирусов

• Main Authors: Dorohova L.N., Shaboldin A.M., Narolenko L.N., Mozes V.G.
• Format: Article
• Language: Russian
• Published: Saratov State Medical University 2010-09-01
• Series: Саратовский научно-медицинский журнал
• Subjects: cellular immunity; cytomegalovirus; pregnancy; undifferentiated forms of dysplasia of connective tissue; virus of herpes simplex
• Online Access: http://www.ssmj.ru/system/files/201003_531_535.pdf

The research goal is to determine the risk of infectious process development in placenta of women with undifferenti-ated forms of dysplasia of connective tissue (UFDCT) by agents - herpes viruses (VHG - virus of herpes simplex and cytomegalovirus). Persistent infection of VHG was revealed in 133 women in the 1 st trimester of pregnancy. All the patients had phe-notypic manifestations of UFDCT; in the 3d trimester of pregnancy immunogram of the second level, histological study of placenta, identification of antigens of VHG family, serological study of placental blood and isolation of DNA of VHG were carried out. All newborns were clinically and laboratory tested on VHG infection. As pregnant women with UFDCT had high risk of VHG infection development in placenta, they suffered from placental insufficiency. It resulted in unfavourable perinatal outcomes. VHG infection development was caused by disturbances of cellular immunity. Key words: undifferentiated forms of dysplasia of connective tissue, virus of herpes simplex, cytomegalovirus, cellular immunity, pregnancy